[WCIR2009]生物钟与糖尿病--P.Grant教授访谈
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专家访谈 综合领域 作者:PeterJ.Grant 来源:未知 2009/12/1 10:00:00    加入收藏
内容概要:《国际糖尿病》:您出色的研究发现胰岛素抵抗和一些与血栓形成有关的因子之间显著相关。胰岛素抵抗的个体凝血-抗凝系统最主要的特征性改变是什么?

    International Diabetes : Switching subjects completely, you were in the session that talked about circadian rhythm and in fact Dr Bloomberg describes your talk as “disrupt your clock at your own peril”.  Could you please describe for us what that means?

《国际糖尿病》:换个话题吧,您在开会期间谈论过昼夜节律性,而实际上Bloomberg将您的谈话描述为“以自己患病的危险来破坏你的生物钟”,您能解释一下这是什么意思吗?

    Dr Grant : Yeah I think at a philosophical level I think one of the conceits that humans have is that they are not a part of the natural world.  We have created our own cities and we live our life away from apparently natural influences and I think that you could say that most of the modern problems that we face in terms of disease is being out of touch with our biology and our biology is the clock is there to push on our metabolism and our functions in time with our daily requirements at different times a day so you want your metabolism switched on when you get up in the morning and you want it switched off when you go to bed at night.  And the cues that develop those kinds of changes are visual and they are food related and of course what we have done in the last hundreds of years is that we have changed 3 to 6 million years of habit where we would live our lives according to the seasonal availability of food and the daily availability of light and we have completely exposed ourselves to 24/7 life.  And I think those changes that we have allowed ourselves to be exposed to in the last 100 years or so is the cause of diabetes and heart disease and possibility cancer and other things as well.  
Grant教授:好的。我认为,在哲学上有一些人有一种想法认为他们不是自然界的一部分。我们创造了我们自己的城市,我们的生活表面上不受自然界的影响。我想你也可能会说我们所面对的许多现代问题例如疾病,与我们的生物规律无关。我们生物规律就是一个时钟,它促进我们的新陈代谢和改变各种功能,以及时满足一天中不同时刻的需要。当早晨你起床的时候你想打开你的新陈代谢,而晚上你睡觉的时候你想将它关闭。产生各种改变的信号是视觉、食物相关的,当然也和数百年来我们所做的改变有关。数百年来我们改变了我们三百万—六百万年前的栖息之地,我们曾在那里过着根据季节利用食物、白天利用光线将自己完全暴露的生活。我认为最近100年左右我们所经历的改变是糖尿病、心脏病的产生的原因,也使肿瘤和其它疾病成为可能。
 



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